Bee Propolis: Synergisitc condition Care for the 21st Centruy
For well over a century contemporary science has progressed at a thinkable, rate. With this increase in knowledge has come restorative and healthcare benefits that have seen ages peak and diseases eradicated. These healing advances were based colse to the paradigm of the "magic bullet", isolating the active ingredient and using it to alter the chemistry of a single molecule/protein to elicit a convert of state in the patient. Success however has turned to obsession as cracks appear in the armoury of disease fighting drugs at our disposal. Mrsa is rifling through our hospitals as antibiotics become ineffective and severe side effects of contemporary drugs are becoming coarse place now years after their introduction. A direct consequence of a one dimensional strategy, it is maybe the time to retort the synergistic condition benefits of natural medicine.
Propolis is a unique natural rehabilitation because of its breadth of action. It has antibacterial, antiviral, antifungal, anti-inflammatory, anti-cancer and immunomodulatory effects, it could help treat asthma, allergies, arthritis and joint disorders, eczema and dermatitis, Me, viral infections including Hiv and even cancer. This rehabilitation could help treat an illness or keep you fit and healthy.
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Propolis: Defender of the City
Propolis is a mainly resinous substance that bees gather from trees and plants. Being made up of waxes, resins, fatty acids and even amino acids. Aristotle reputedly coined the name Propolis meaning "defender of the city". This is exactly what Propolis is for the hive, it acts as a bee population's external immune principles holding the hive sterile and free of microbial invaders
Evidence Based Medicine
In the following paragraphs I will chronicle to you the pharmacological properties of Propolis. Before I do so I must explain where this evidence comes from. All the properties and actions of Propolis have been witnessed and detailed in scientific studies which have subsequently been published in journals. The bulk of these scientific studies have been performed in vitro (i.e. In a test tube) or in vivo (i.e. In a host animal for example rats), a much smaller proportion of these studies are clinical trials tested on humans. The abstracts of these papers can be found on the Medline and pubmed databases on the Internet.
Propolis: A natural antibiotic
Propolis is probably best known for its antibiotic properties. Even as early as 1960 French1 explore demonstrated the bacteriostatic action on Bacillus subtilis, Proteus vulgaris and Bacillus alvei. The results have been replicated many times and Propolis has even been shown to be sufficient to Mrsa2, the same antibiotic resistant bacteria that has infected up to 70% of our hospitals. A 1997 study by Calder et al. At the University of Oxford concurred with these results and found that the cinnaminic acids and flavanoids gift in Propolis in single show bacteriocidal action. This action believed to be as a consequence of Propolis uncoupling the bacterial power respiratory chain. Interestingly this action may be complicated in a synergistic action with antibiotics when used together, boosting the effectiveness of the drugs.
Anti-Viral and immuno-stimulatory
Viruses gift a unique dilemma in the quest for good health, they are not affected by antibiotics and mutate so oftentimes that vaccines are hard to produce. They also cause illness by hijacking cells and using the cells machinery to replicate. contemporary drugs aim to slow or stop the virus from the replicating and subsequently because they are attacking host cell machinery they have clear side effects. Viruses maybe pose the most threat to humans' health, we are currently in the middle of a Hiv pandemic with "39.4 million" citizen infected world wide. With a Flu pandemic overdue and truly on its way and predictions of world wide casualties and chaos, a solution is needed.
The bioflavanoids in propolis have a unique advent to combating Viruses, instead of trying to combat them once they have infected a cell, they lock the virus in its protein coat. This means that the dangerous machinery and Dna/Rna of the virus is nullified and the infection stopped.
Propolis has been shown to be more sufficient than the pharmaceutical anti-viral acyclovir in treating genital Herpes in a clinical trial conducted in the Ukraine4 and there is growing evidence that Propolis could help treat citizen with Hiv5.
Propolis also works hard as an immunomodulator which is of interest for all of us. It does this by altering the way cytokine yield and issue is managed. Cytokines are the chemical messengers that allow immune principles cells to communicate. By altering the cytokine system, it primes the immune principles to be ready to react to antigens quickly and effectively.
As well as this, bioflavanoids within Propolis stimulate the yield of interferon which can help citizen recover from Me, stimulating their immune system. This alteration of the cytokine and interferon systems means that your body is ready to fight off infection and keep you healthy, development a case for using propolis as a supplement for good health, like vitamins. Prevention is great than the cure.
Anti-inflammatory and anti-allergen
A eye of Propolis consumers showed that arthritis was the condition qoute that Propolis was used to treat the most. This is because of the potent anti-inflammatory properties of the propolis constituents in single Cape (Caffeic acid Phenyl ester), Cape has been shown to suppress T cell activation. A paper by Marquez et al in 20046 evaluated this to mean that since T-cells play a key role in the onset of any inflammatory diseases, Cape is prominent because the this phenolic composition is a potent inhibitor of early and late events in T-cell receptor-mediated T-cell activation. Results like this have led other researchers to propose that Cape is a worthwhile agent for reducing the severity of conditions related with inflammation.
Many of the experiments performed on Cape were done so in vitro, however the anti-inflammatory properties of Propolis have been documented in rats when treating rat adjuvant arthritis. A paper by Park et al in 19997 concluding that the ethanolic citation of propolis had profound anti-inflammatory effects on both persisting and acute arthritic inflammations. These anti-inflammation properties increase to other illness and disorders such as asthma and allergies reducing both smooth muscle airway contraction8 and allergic responses. Any disorder or illness related to inflammation could be helped by Propolis.
Anti-tumour/cancer
Propolis and Cape have been shown to sacrifice the size of tumours and to selectively destroy and to curb the proliferation of malignant cells of many dissimilar types of cancer. As recently as June 10th 2005 Cancer researchers have been given a grant of a million dollars to explore the therapeutic value of Propolis for cancer. Costas Koumenis the lead interpreter for the study was quoted as saying, "a very curious asset of these compounds is that they have been shown to cause cell death in tumor cells but not in general cells." This study along with other current studies promises to drive Propolis into the limelight in the field of cancer treatment.
Current Propolis explore in the Uk
Bvr (BeeVital Research) recently won a major government explore and amelioration Award, part of a £250,000 explore programme looking at the chemical, biological and clinical properties of propolis.
These studies will focus on the:
1. Documenting the regional variances in chemical and biological properties, by Hpls, Gc-Ms and Nmr. (Taking place at Univeristy of Strathclyde)
2. Futher investigating the role of Propolis in the Hive (University of Gloucester)
3. Dental trials - looking at effectiveness of Propolis for Mouth Ulcers, Pericorinitis, Gingivitis and Sensitive Teeth. (Manchester University Dental school)
4. Hiv/Aids trials - looking at the effectiveness of Propolis with anti-virals in Zambia and Tanzania
5. The effects of standardised propolis on mood, stress, fatigue and cognition at the Human Cognitive Neuroscience Unit at University of Newcastle.
6. To value the use of local and non - local propolis for wound healing and the rehabilitation of skin and other dermatological problems. ( The Regional Teaching Hospital for University of Dar es Salaam)
How to use/find propolis products?
A large range of propolis products are available on the store fluctuating from tablets, capsules, tinctures and liquids to specialist products for skin care - soap, lip balm, creams and oral condition care - toothpaste, mouthwash , lozenges and tooth and gum liquid.
Traditionally these have been available through condition food market but are increasingly available in independent pharmacies.
Choosing the best products is not always easy. Current regulations means manufacturers cannot make any kind of healing claim for products that have not been licensed as medicines despite the fact that there is a sound evidence basis for such claims. Part of the guess for this is that no single body is responsible for ensuring that goods offered for sale truly are what they say they are.
For this guess the Bvr (BeeVital Research) programme is targeted at developing full medicines licenses for some key products. In the meantime Bvr have formulated a estimate of products for the condition food store based on their research. Consumers, when purchasing products should look for those products produced by companies who can back up their products by good manufacturing custom (pharmaceutical suitable manufacturing ) and research.
References:
(1)Lavie, P. (1960). Annals Abeille, 3: 103-201
(2)Anti-Bacterial properties of propolis. Grange, J. M., Davey, R. W. Journal of the Royal society of Medicine, 83: 160-1 (1990)
(3)Anti-microbial action of propolis and some of its components: The effect on increase membrane inherent and motility of bacteria. Mirzoeva, O. K., Grishanin, r. N., Calder, p. C. Microbial - res, 152: 239-246 (1997)
(4)A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the rehabilitation of genital herpes (Hsv). Vynograd, N.; Vynograd, I.; Sosnowski, Z. found of Epidemiology, Lvov State healing University, Lvov, Ukraine. Phytomedicine (2000), 7(1), 1-6. Coden: Pytoey Issn: 0944-7113.
(5)Current lead natural products for the chemotherapy of human immunodeficiency virus (Hiv) infection. De Clercq, Erik. Rega found for healing Research, Katholieke Universiteit Leuven, Louvain, Belg. restorative explore Reviews (2000), 20(5), 323-349. Coden: Mrredd Issn: 0198-6325
(6)Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and Nf-B transcription factors. Marquez, Nieves; Sancho, Rocio; Macho, Antonio; Calzado, Marco A.; Fiebich, Bernd L.; Munoz, Eduardo. Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Facultad de Medicina, Cordoba, Spain. Journal of Pharmacology and Experimental Therapeutics (2004), 308(3), 993-1001. Coden: Jpetab Issn: 0022-3565.
(7)Suppressive effects of propolis in rat adjuvant arthritis. Park, Eun-Hee; Kahng, Ja-Hoon. College of Pharmacy, Sookmyung Women's University, Seoul, S. Korea. Archives of Pharmacal explore (1999), 22(6), 554-558. Coden: Aphrdq Issn: 0253-6269.
(8)Bulgarian propolis induces analgesic and anti-inflammatory effects in mice and inhibits in vitro contraction of airway smooth muscle. Paulino, Niraldo; Dantas, Andreia Pires; Bankova, Vassya; Longhi, Daniela Taggliari; Scremin, Amarilis; Lisboa de Castro, Solange; Calixto, Joao Batista. Grupo de Pesquisa e Desenvolvimento de Biofarmacos (Biofar), Universidade do Sul de Santa Catarina, Tubarao, Brazil. Journal of Pharmacological Sciences (Tokyo, Japan) (2003), 93(3), 307-313. Coden: Jpstgj Issn: 1347-8613.
Bee Propolis: Synergisitc condition Care for the 21st Centruy
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